Line: 49ers by 7. Over/under: 40.
Niners are hitting their stride with Colin Kaepernick, and they've won four of five in St. Louis. Rams' best hope is to get Steven Jackson rolling.
Jaguars (2-9) at Bills (4-7), noon
Line: Bills by 6. Over/under: 45.
Teams are pretty evenly matched, with Jaguars getting a little better with Chad Henne and banged-up Bills struggling of late. Being at home counts.
Pick: Bills 24, Jaguars 21.
Colts (7-4) at Lions (4-7), noon
Line: Lions by 5. Over/under: 51.
Bills got to Andrew Luck four times in Colts' last game. Lions will feast on any protection breakdowns, especially when Luck will be throwing often to keep pace.
Pick: Lions 31, Colts 28.
Patriots (8-3) at Dolphins (5-6), noon
Line: Patriots by 9. Over/under: 51.5.
Patriots are averaging 435.8 yards and 37 points. It's tough for any opposing quarterback to respond to that firepower, especially a rookie.
Pick: Patriots 35, Dolphins 24.
Texans (10-1) at Titans (4-7), noon
Line: Texans by 6. Over/under: 47.
Titans' Chris Johnson had a big game last time these teams met, and Texans still won by 24. Playoff-bound Texans are simply a better team.
Pick: Texans 28, Titans 20.
Buccaneers (6-5) at Broncos (8-3), 3:05 p.m.