"I haven't thrown up after a race yet, so maybe that is what I have to shoot for," she said, with a grin.
Ledecky won the 200 and 800 freestyles earlier in the meet. She has decided to skip Sunday's 1,500 to get back into training for the Pan Pacific Games, which begin Aug. 21 in Australia.
"I just like to train hard and swim fast," she said. "I'm glad it's paying off."
Grevers was "pleasantly surprised" by his time in Saturday morning's heats of the 100 backstroke, and no wonder.
His clocking of 53.11 was fourth fastest in the world this season. China's Yu Jiayu is the leader at 52.34.
Grevers, 29, the Olympic 100 back champion, was even faster in the final, winning in 52.75 (third fastest of 2014) even though he bounced around his lane and "probably swam 102 yards."
"I think I'm in the best shape of my life," he said.
In the 100 breaststroke, favored Kevin Cordes of Naperville had the fastest time in the heats but wound up third in the final with a slower time. Cordes clocked 1:00.63 to winner Cody Miller's 59.91.
In finishing fifth to Missy Franklin (59.38) in the 100 backstroke, Glenview's Olivia Smoliga (1:01:08) matched her finish of last year and achieved her goal for a national meet she entered after losing recent training to a bout with mononucleosis.
It was Franklin's third victory of the meet.