The host dedicated a 10-minute segment to Williams, recalling their earliest interactions at The Comedy Store in Los Angeles when both stand-up comedians were just starting their careers. Letterman noted that Williams' performance was like "nothing we'd ever seen before... we're like morning dew, he comes in like a hurricane. The longer he was on stage, the worse we feel about ourselves, because it's not stopping. And then he finishes, and I thought, 'oh, that's it, they're gonna have to put an end to showbusiness, because what can happen after this?'"
"Beyond being a very talented man and a good friend and a gentleman, I'm sorry -- like everyone else -- I had no idea that the man was in pain, that the man was suffering," he said. "But what a guy."