Jensen, who is from Scotland, and Beesley, from England, have used the midcentury house to host visitors from Britain and to entertain.
"We wanted a house that we knew we were in L.A.," Jensen said. "There's an amazing view of not only the cityscape, but you can also see the sea on certain days."
The 2,404-square-foot house incorporates steel, tile and glass in a minimalist approach. "It's not too much fuss," she said. There are three bedrooms and 21/2 bathrooms.
Jensen liked living near the studios when shooting "Ugly Betty" (2006-10). "Yet you feel like you are in the middle of the countryside and you have deer and skunks," she said. "You are in among nature, yet you can walk to the grocery, bars, restaurants and can even walk to the farmers market."
The pair put in an infinity pool that has a view of Hollywood, and Beesley designed the terrace and exterior space. "We tried to make it … David Hockney," Jensen said of the pool. "On bright shiny days it's very blue."
They are selling because they would like a house that is more toddler-friendly with a flat lawn.
Jensen was in the just-released "Gnomeo & Juliet" and is working on other animated projects while splitting her time between L.A. and London. Beesley is writing a pilot.
The property was purchased in 2007 for $1.65 million, according to public records.
Jacqueline Gowers of Sotheby's International Realty, Los Feliz, is the listing agent.