He built the Umbria-inspired country home after the house he had on the site was destroyed in a 2008 wild fire.
Lloyd, 73, is widely known for his roles in the sitcom "Taxi" (1978-83) and the "Back to the Future" trilogy. He is working on a comedy pilot for ABC.
The Emmy-winning actor is selling because he is downsizing his real estate holdings and spending more time in New Mexico.
Lisa Loiacono of Sotheby's International Realty is the listing agent.